@manofheart
Disorders of the parathyroid gland, particularly hyperparathyroidism (excessive parathyroid hormone or PTH), are associated with an increased incidence of cardiovascular complications, including vascular and valvular calcification, which can be measured by a cardiac calcium score (CAC score).
Key connections include:

Calcium Homeostasis: The parathyroid glands are the primary regulators of calcium balance in the body. Disruptions in this function lead to abnormal calcium levels in the blood, which can, in turn, affect the cardiovascular system.
Increased Calcification Risk: Chronic elevated levels of PTH and calcium, as seen in primary or secondary hyperparathyroidism, contribute to calcium deposition in the heart muscle, heart valves (mitral and aortic), and coronary arteries.
Higher CAC Scores: Studies have shown that patients with primary hyperparathyroidism often have significantly higher CAC scores compared to the general population, suggesting a greater burden of coronary atherosclerosis.
Cardiovascular Mortality: The calcific diseases and other heart issues (like hypertension, arrhythmias, and heart failure) linked to parathyroid disorders translate into increased cardiac morbidity and mortality.
Potential Reversal: Early treatment of parathyroid disorders, such as parathyroidectomy (surgical removal of the overactive gland), may prevent the progression of these calcifications and other cardiovascular problems.

While some smaller studies have shown conflicting results regarding the direct correlation between PTH levels and CAC scores in specific populations (e.g., patients with normal renal function or who are asymptomatic), the overall body of research indicates a strong association between abnormal parathyroid function and cardiac calcification.

Yes, parathyroids have everything to do with calcification of the arteries!