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DiscussionOrchiectomy and PSA decline waiting for Liver Transplant
Prostate Cancer | Last Active: Nov 1 10:29am | Replies (4)Comment receiving replies
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@seeker001
Lupron is not processed by the liver's cytochrome P450 system, but it can affect the liver and may cause liver test abnormalities. Instead of being metabolized by the liver, it is broken down locally in many tissues and primarily by peptidases in the systemic circulation.
Liver effects: Despite not being processed by the liver, Lupron therapy can cause liver test abnormalities. These can sometimes be linked to weight gain or other metabolic changes, such as nonalcoholic fatty liver disease (NAFLD), which can arise from the low-testosterone state induced by the drug. This would cause the same problem with any ADT drugs.
On the other hand Orgovyx Is processed by the liver.
You should speak to your doctor about this before stopping Lupron.