@ali77 I could really ask the same question that you have. I have been on it for 3 wks., and have been hoping against hope that the side effects lessen. I have a mild to moderate headache pretty much 24/7, and get so tired by the afternoon each day that I really have to push myself to do anything more. My GI tract is so messed up, with constipation, and some episodes of nausea and vomiting in the middle of the night, some 2-3 hrs after the shot. My memory and ability to concentrate are worse, as are my joint pains.My doctor doesn't seen too interested in any of these things, since they are known to be side effects of this drug, so I sincerely hope they decrease. I am 77 yrs old, but a busy person, and don't wish to be semi-sick for two years.. Best wishes for you in this adventure!