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Hot flashes more than a year after ending treatment
Prostate Cancer | Last Active: Oct 30 5:26pm | Replies (28)Comment receiving replies
While this test does show that 1/3 of men could benefit from NOT having 24 weeks of ADT the biomarker that can tell who that one third are, is still not available. 2/3 of men in the study did benefit from ADT for 24 months.
“About two-thirds of the men had a positive biomarker, meaning that they benefited from the two years of hormonal therapy,” said Andrew Armstrong, MD, director of research for the DCI Center for Prostate and Urologic Cancers. “But one third of the men did not—they had no added risk of cancer spreading or coming back. That would save a third of all high-risk men that extra 18 months of hormonal therapy.”
We sought to develop a biomarker using tissue that could identify patients that really need those two years of hormonal therapy, or patients that could have excellent outcomes and not have to spend two years on hormonal therapy,” Armstrong said.
While the development and validation of the biomarker is complete, the team is now moving toward commercialization and creating a product that can be approved and used by doctors.
More information is available in this link
https://www.dukecancerinstitute.org/blogs/ai-tool-may-help-some-prostate-cancer-patients-avoid-hormone-therapy
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@jeffmarc
Thanks for the additional information. Reading the Duke paper alone would leave the average person like me, to believe that low testosterone levels due to hormone treatment would strongly increase the chances of aggressive cancer spreading in high-risk patients.
It seems that it is very difficult to properly classify each patient's cancer aggressiveness. My Gleason level indicated my cancer had reached the entrance of the seminal duct but not spread outside the prostate and I was rated as 3Tb. I had serious side effects from 44 radiation treatments (diarrhea and tenesmus), and the side effects from Lupron were even worse with heavy sweats 24 hours/day, frequent urination, severe headaches, body muscle and joint pain, and brain fog. It got worse every day, and I had to stop Lupron after 4 months. Now 4 months after stopping, I am just starting to get rid of the side effects and have had two PSA test < 0.1 ng/mL and two testosterone levels < 8.7 ng/dL. I will just have to wait and see what my test will look like in 3 more months.