Connect
← Return to Anyone had a significant AR-V7 variant? What treatment?
Discussion
Anyone had a significant AR-V7 variant? What treatment?
Prostate Cancer | Last Active: Oct 31 6:46pm | Replies (12)Comment receiving replies
@jeffmarc Do you have a link to the appropriate tapering schedule for prednisone? My husband took it for over three years with Zytiga. Since stopping Zytiga when it stopped working, he has gone down to 5 mg of prednisone per day. Then he was told by the local medical oncologist to go down to 5 mg every other day. He is so exhausted and weak and has other problems that make me suspect prednisone withdrawal. I don't think the doctor is well informed on prednisone tapering. If you could point me to some resources, I would really appreciate it.
Replies to "@jeffmarc Do you have a link to the appropriate tapering schedule for prednisone? My husband took..."
Connect
@lag
I know of no published tapering instructions that I could give you.
This was discussed months ago, at one of the ancan.org Weekly advanced prostate cancer online meetings. A number of people had problems with stopping too quickly, and as they were talking, I realized I had exactly the same problem, I was exhausted in the afternoon and had to sleep, Something I normally didn’t do.
Somebody that’s on 5 mg needs to cut down to 2 1/2 mg for two or three weeks and then alternate that every other day for a couple of weeks and maybe even cut that in half for a week or two. So many people have this really fast, fatigue problem because they drop it too quickly.
One guy I was working with (Imerman Angels) ended up getting 1 mg prednisone tablets from his doctor so he could taper even more slowly. He was just exhausted after trying to come down from 10 mg too quickly. In his case he had to move up to 10 mg because he was so tired with just five. It took him at least four or five months to taper down.