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Just diagnosed: Surgery not an option, looking for hope
Colorectal Cancer | Last Active: Mar 12 8:29pm | Replies (98)Comment receiving replies
@vcsongradi
Hi I am colon cancer stage 3B. Just wondering if you have the molecular analysis of your tumor. (also called Genomic or Tumor Markers) Then you might be able to get Targeted Therapy. . i.e. the type of chemotherapy could be different based on which mutations they find in the specimen (either from biopsy or surgery). If you have KRAS G12C or D, there are specific drugs. Unfortunately, Targeted Therapy is not available for all mutations. If you are dMMR (deficient mismatch repair also know as Microsatellite Instability) then you could get immunotherapy. dMMR is less common, only about 5-15% of colorectal cancers. But certainly worth asking.
Replies to "@vcsongradi Hi I am colon cancer stage 3B. Just wondering if you have the molecular analysis..."
@cliffe75
This is the result of examining tissue at the MD Anderson laboratory.
Rectum, mass, biopsy:
INVASIVE, MODERATELY DIFFERENTIATED ADENOCARCINOMA. (SEE COMMENT)
Comment
Immunohistochemical studies were performed at the outside institution and reviewed at MD Anderson. The tumor shows preserved nuclear expression of MLH1, PMS2, MSH2 and MSH6. Therefore, the likelihood of defective DNA mismatch repair/high levels of microsatellite instability (MSI-H) in the tumor is low.
I also had DNA analysis done and there was nothing significant found that would benefit from targeted therapy.
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@cliffe75 Absolutely, check these things out…i had a rare and aggressive tumor, dMMR and immunotherapy knocked out all the cancer in only a few treatments…and surgery followed up….i had told the oncologist I really wanted an alternative to chemo…and the genetic testing was key. Good luck !