@maysh47 I too am chasing away a profound family history of AD. I am on low dose Lithium Orotate (AMA). Sadly the speed to get to human trials is on a timetable that is slower than I fear disease progression will be. So I am taking the supplement dose of 5mg - and doing anything else I can.

If you aren’t aware, there is a freaking miraculous trial at WestVA U. They won’t take me Because of my APOE4. But they have a process to open the blood brain barrier with targeted ultrasound and put meds directly on plaque/Tau. - and it goes away. But prying open BBB introduces risk of brain bleed.

Here is AI Summary and look for a 60 minutes special on it a couple of years ago

AI
West Virginia University (WVU) has a prominent trial at its Rockefeller Neuroscience Institute (RNI) that uses a combination of focused ultrasound and Alzheimer's antibody drugs. The trial aims to improve drug delivery to the brain to reduce amyloid plaques and potentially slow cognitive decline, and has seen promising results like a greater reduction of plaques in targeted brain areas compared to non-targeted areas.

About the WVU RNI trial

Method: The trial uses focused ultrasound to temporarily open the blood-brain barrier, allowing Alzheimer's-treating antibodies to penetrate more effectively into targeted areas of the brain.

Goal: To accelerate the reduction of amyloid plaques and improve cognitive outcomes for patients with early-stage Alzheimer's.

Progress: Initial trials showed the procedure was safe and successful in opening the blood-brain barrier, and later studies showed an increased reduction of plaques in treated areas.

Next steps: The team is moving into the next phase to further accelerate plaque removal with the focused ultrasound and lecanemab antibody drug.

Collaboration: The WVU team has also been working with West Virginia University Medicine and collaborated with INSIGHTEC, an Israeli medical technology company, on this research.