@bswpb I noticed a difference after 6 months. My guess is it would vary depending on what ailment it is treating. I know if is most often used for RA - the nurses who administered by first set of infusions stated they had never treated my particular autoimmune disorder, ELP, before. I convinced my gastroenterologist to let me try it after reading a medical journal article about someone with my condition being successfully treated with it. That was one year ago.