@sasham My husband's thoughts are we have to try something, that is why he is getting the infusions. We are trying to prolong our quality time together and I cherish every day. It is not the right choice for everyone as circumstances are different. Next week will be infusion #48. He has not missed one on this journey. We had a PET scan done in August 2025 to compare to the one we had done November 2023 and the amyloid plaque was reduced from 78 to 12 on the scale they used to measure. Because there is still plaque present, he is considered amyloid positive and Mayo doctors recommended staying on the 2 week regimen until February and repeat PET scan. This is what we will do as we trust the Mayo doctors. You will make the decision that is right for the two of you.

@sasham i am pea green with envy for your husband’s gene pairing. A 2/3 is awesome in my book. I have 3/4 and that instance of 4 increases the risk of brain bleeds. I told my neurologist the day may come when I am willing to take the risk - but it’s not today. An instance of 2 improves chances of not developing AD as I understand it.