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Anyone have experience with triplet therapy?
Prostate Cancer | Last Active: Oct 29 11:57am | Replies (14)Comment receiving replies
@kujhawk1978 Thanks for sharing your story. At first I was disappointed to hear they didn’t want to do any salvage radiation and wanted to go right to chemo. After reading more and hearing from others I’m getting used to the idea of attacking it systemically only. On Orgovyx and Nubequa now and PSA is going down nicely. Doc says better to “hit it hard” the sooner the better. May I ask what happened after your five year hiatus from treatment?
Replies to "@kujhawk1978 Thanks for sharing your story. At first I was disappointed to hear they didn’t want..."
@ucla2025
In March 2022, my PSA began a continuous climb over the next 12 months...
.12
.22
.48
.7
.77
That met our first and second decision criteria, three or more PSA tests showing an increase and between .5-1.0.
We imaged, it showed a single lymph node.
I met with my radiologist and oncologist. My going in position was SBRT to the lone lymph node and six months ADT, Orgovyx, in part based on the SPORT trial.
Radiologist supported that. Oncologist advocated for SBRT but 24 months ADT + ARI, aka, EMBARK trial.
We settled on SBRT, 12 months Orgovyx, hold the ARI, add only if PSA did not drop to undetectable in first three months, revisit our decision at 12 months, decide to come off or continue in three months increments, deciding at that point, continue, come off.
At the 12 month consultation, we agreed to come off treatment. Well, my oncologist supported my request to come off treatment, I know he would have liked me to do the full 24 with the ARI.
\Who was right, me. the oncologist? We'll never know. Like I said, make the best decision, don't look back.
At 20 months since our decision, only thing I know is we made a good decision.
As a side note, this disease has terms and definitions. When you say "salvage radiation" it generally means SRT - Salvage Radiation Therapy, which is radiation after BCR to the prostate bed only vice WPLN - Whole Pelvic Lymph Node or MDT - Metastases Directed Therapy. Given your clinical data, any radiation likely is MDT but only if imaging shows where to target and generally if no more than 3-5 sites.
Kevin
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@ucla2025
One thing you need to realize is that everybody is different In their results with prostate cancer,. Some people will have great results after chemo. Some people won’t. There’s no way of knowing where you will fit. The experience of others may not be the experience you have.
In my case salvage radiation gave me 2 1/2 more years before my PSA came back up. The thing is, you don’t do salvage radiation, when there are too many known metastasis. That’s why your doctor wants to do chemo.
You can do Pluvicto which Was not available to @kujhawk1978. Here are some things to consider before doing Pluvicto
Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people. If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer, it will also show hereditary issues.
If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.