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Is there a negative interaction taking probiotics while on prednisone?
Polymyalgia Rheumatica (PMR) | Last Active: Oct 27, 2025 | Replies (13)Comment receiving replies
I have never hear that. In fact I was taking a ppi (pantoprazole ) for GERD and since taking my prednisone with kefir, I have not needed the ppi. Kefir has a ton more of good bacteria in it than yogurt and most probiotics.
Replies to "I have never hear that. In fact I was taking a ppi (pantoprazole ) for GERD..."
@vjm0223
I think the kefir is fine. It’s the probiotic supplements which sound like they are a problem.
The ppi causes a decrease of stomach acid which in turn can be a problem causing diarrhea. If gut bacteria isn’t in balance bad stuff happens.
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@vjm0223
Just experienced a bout of diarrhea today for the first time in decades. Been on pantoprozole for about a month to control excess stomach acid and GI discomfort while on prednisone. Wondering if the pantoprozole is causing it. I eat yogurt and drink kefir. Maybe I should take the prednisone with kefir as well.