@marieirene
I have skin tested allergic to wheat , but never really followed a no wheat diet .But after failing other RA meds for one reason or another, I was left with taking sulfasalzine and a small dose of prednisone which really isn't keeping me pain free.
I suspect it is the lower doses of prednisone that is causing your symptoms to increase. Last year I weaned off of 10 mg daily over a period of 3-4 months. Perhaps that was too fast, but at any rate, I could not remain prednisone free. I'm managing, barely, on 5 mg now.
Simponi Aria was one of the meds I failed. My RA symptoms actually got better after my first infusion, and I was so hopeful I could continue it. But about a week after that infusion I began to have cardiac issues , so could not.

After all that, I decided to take my wheat allergy seriously and stop eating wheat. It is really hard to do, but it makes a big difference for me and on rare occasions when I cheat, the aching and severe fatigue starts all over again. There is literature that suggest that a lot of people with RA do better when they give up wheat.

Another thing is perhaps taking fish oil might help. I started taking it 6 months after I was diagnosed 25 years ago. There have been good studies that show that taking it for RA eliminates the need for pain meds in some RA patients. There is good information online about how to take it and the dosages used in studies that were done.
I have never been overweight, but I know that for people who are, it is harder to manage their disease.
My daughter has sero-negative RA and she is quite overweight and is having a harder time than I've ever had.