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Lupron v. orgovyx...which is preferable for the heart?
have A/FIB and CHF, drugs: xarelto amd metropolol. metastatic Prostate cancer in lungs and some lymph glands, caught early. began LUPRON/NUBEQA in april. effective. since july, Testosterone = 13 and PSA < 0.01, ie: undetectable. side effects, i handle it.
what me and the docs are looking for is info, any advantage of Orgovyx v. Lupron. any reason to switch . any advantage for heart function.? diminuation of risk?
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FWIW...I am a CHF patient as well. I was put on Orgovyx/Nubeqa with concurrence from my Cardio-Oncologist after consult with my Genito-Urinary Oncologist.
From the below linked article, "Recent data reinforces that GnRH antagonists have a more favorable cardiovascular outcomes compared to GnRH agonists yet maintain a similar efficacy profile."
The studies referenced in the article, and the article itself, along with an echo EF of 30-35%, were used for pre-auth to get my insurance company to cover it.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8254069/
Best wishes!
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5 ReactionsGnRH: Gonadotropin Releasing Hormone
Antagonists of GnRH:
LUPRON [ELIGARD], (leuprolide)
ORGOVYX, (relugolix)
An advantage of ORGOVYX may be that its effects are daily and withdrawal has immediate results but heart effects may relate to its cumulative effect to the point when stopped. [Lay opinion]
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2 Reactions@thmssllvn Correction: Lupron is a GnRH agonist. Orgovyx is a GnRH antagonist. Different mechanisms of action.
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3 ReactionsWhile the following information discusses the comparison even if the person taking Lupron has Casodex for a couple of weeks before a lupron injection.
When it comes to heart-related side effects, Orgovyx (relugolix), a GnRH antagonist, has consistently been shown to have a more favorable cardiovascular profile than Lupron (leuprolide), a GnRH agonist, even when a "flare-reducing" drug like Casodex is used before starting Lupron. The key difference lies in their mechanism of action and the resulting effects on testosterone levels.
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5 ReactionsThe only thing I know of is one’s a pill form and Lupron is an injection
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2 Reactions@mjp0512 thank you
from biddaddyalso.......after reading the meta study y'all named i decided to do the switch, as the ONC suggested, pending ok from cardio. info lacking in summary IE: who are subjects incomplete so unsure if my CHF is included and and etc?. but writer clear about the relative disadvantages of agonists (LUPRON)over time. i did not read yet any of the studies referenced. also, there is a risk with orgovyx related to "long QT syndrome"
a restraint to orgovyx is cost. 2k monthly. with medicare DR. Google say $100 mthy. add the NUBEQA , well do the math. this year. max out of pocket drog is $2,100, of this i am certain. otherwise i couldnot afford.
@bigdaddyalso
I have afib which is particularly susceptible to long QT syndrome. I have a couple events specifically caused by it when I was on Zytiga and Lupron.
I have never had a problem since I’ve been on Orgovyx and Nubeqa.
Just another point of view.