I started Ohtuvayre 7/24/25. No effect noted, but 8/8 I had an episode of severe epigastric pain, lasted a day. The next day it was gone but I was very tired, took things easy for a week and a half and lightened diet etc. Returned to rehab 8/23 but found my stamina was less, my heartrate was elevated, and didn't feel as well. I also found my shortness of breath had drastically gotten worse, to the point I could hardly walk from room to room without feeling breathless. Normally I only needed oxygen during the day with fairly heavy exertion. I was also exhausted, felt pressure in lung area and was starting to wheeze.

I continued to take the Ohtuvayre, but started looking online for info, and came upon this site. I saw that some other people had had a severe reaction as I was, and so on 9/18 I stopped the medication. Within three or four days my SOB subsided, energy level and heart rate improved and I felt much better. I'm back to my "normal" level of emphysema now. I have stage 4 and also pulmonary hypertension, but have done very well managing it with LTOT, Stiolto and good diet and exercise. Don't know why Ohtuvayre did not work for me, but I gave it eight weeks!