1. < Neuroendocrine Tumors (NETs)
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Severe pain after stage2 y90 treatment

Posted by baker23 @baker23, Jun 24 2:10pm

5 days ago I had y90 embolization to the liver for metastatic nonfunctional NET. Severe pain and vomiting after procedure. Had to be admitted for 3 days. At home now. Still in pain and constipated. Stopped opioid use yesterday. Pain was so bad I was screaming coming out of the procedure. Anyone else experience this?

Interested in more discussions like this? Go to the Neuroendocrine Tumors (NETs) Support Group.

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jespi | @jespi | Oct 23 11:40am
In reply to @hopeful33250 "Hello @jespi and welcome to the NETs support group on Mayo Connect. I'm happy to know..." + (show)
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Hello @jespi and welcome to the NETs support group on Mayo Connect. I'm happy to know that you are looking for answers on your mom's behalf. As this is your first post, would you post a bit about her NETs journey? I'm wondering how long she has been diagnosed and what other treatments she may have had.

I look forward to hearing from you again.

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@hopeful33250

She was diagnosed with HCC liver cancer in the summer of 2024 and has since had one y90 treatment in june 2024 and then had a follow up, aggressive clean up y90 just this past august 2025.

It’s been about 7 weeks since the procedure and it seems like the pain has only gotten worse. She’s been in and out of the ER and her endoscopy shows only dead cells so while it is good that cancer has not spread, she’s still incredibly inflamed.

Searching for answers to take the pain away as it has been incredibly de-habilitating.

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Mentor
Teresa, Volunteer Mentor | @hopeful33250 | Oct 23 12:11pm
In reply to @jespi "@hopeful33250 She was diagnosed with HCC liver cancer in the summer of 2024 and has since..." + (show)
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@hopeful33250

She was diagnosed with HCC liver cancer in the summer of 2024 and has since had one y90 treatment in june 2024 and then had a follow up, aggressive clean up y90 just this past august 2025.

It’s been about 7 weeks since the procedure and it seems like the pain has only gotten worse. She’s been in and out of the ER and her endoscopy shows only dead cells so while it is good that cancer has not spread, she’s still incredibly inflamed.

Searching for answers to take the pain away as it has been incredibly de-habilitating.

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@jespi
I'm so sorry that your mom has not found any help for this pain. Perhaps this would be a good time to get a second opinion. It is always appropriate for a patient to seek a second opinion when they have a persistent issue that their current medical team can't address.

Do you know of a multi-disciplinary medical center that you can contact for a consultation? Mayo Clinic would be a good place to consider (appointment information http://mayocl.in/1mtmR63). If an appointment at Mayo is not possible, a consultation with a university medical school might be appropriate.

Have you considered getting a second opinion?

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jespi | @jespi | Oct 23 1:45pm
In reply to @hopeful33250 "@jespi I'm so sorry that your mom has not found any help for this pain. Perhaps..." + (show)
Profile picture for Teresa, Volunteer Mentor @hopeful33250

@jespi
I'm so sorry that your mom has not found any help for this pain. Perhaps this would be a good time to get a second opinion. It is always appropriate for a patient to seek a second opinion when they have a persistent issue that their current medical team can't address.

Do you know of a multi-disciplinary medical center that you can contact for a consultation? Mayo Clinic would be a good place to consider (appointment information http://mayocl.in/1mtmR63). If an appointment at Mayo is not possible, a consultation with a university medical school might be appropriate.

Have you considered getting a second opinion?

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@hopeful33250

We are exploring it, but we are in California so unfortunately cannot visit a Mayo Clinic. I'll see if we can get help with UCSF or Stanford Medical.

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kevinmonroemi | @kevinmonroemi | Oct 23 5:19pm
In reply to @jespi "@hopeful33250 She was diagnosed with HCC liver cancer in the summer of 2024 and has since..." + (show)
Profile picture for jespi @jespi

@hopeful33250

She was diagnosed with HCC liver cancer in the summer of 2024 and has since had one y90 treatment in june 2024 and then had a follow up, aggressive clean up y90 just this past august 2025.

It’s been about 7 weeks since the procedure and it seems like the pain has only gotten worse. She’s been in and out of the ER and her endoscopy shows only dead cells so while it is good that cancer has not spread, she’s still incredibly inflamed.

Searching for answers to take the pain away as it has been incredibly de-habilitating.

Jump to this post

@jespi It seems to me the interventional radiologist should be able to explain any side effects! I had many tumors but had a healthy liver. Maybe her liver condition was more fragile and couldn’t handle such high dose radiation as well? If you haven’t had a conversation with him I would reach out. Good Luck

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zacharycat | @zacharycat | Oct 24 11:33am

I had bland embolization to liver in Jan 2024. High fever and nausea for days. Didn't eat anything. There was also a burning feeling on the outside of the right leg that still appears from time to time, and is numb most of the time..

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jespi | @jespi | Oct 24 11:59am
In reply to @kevinmonroemi "@jespi It seems to me the interventional radiologist should be able to explain any side effects!..." + (show)
Profile picture for kevinmonroemi @kevinmonroemi

@jespi It seems to me the interventional radiologist should be able to explain any side effects! I had many tumors but had a healthy liver. Maybe her liver condition was more fragile and couldn’t handle such high dose radiation as well? If you haven’t had a conversation with him I would reach out. Good Luck

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@kevinmonroemi Thanks for the concern! She also mostly has a healthy liver as well, just a large tumor - around 9cm. The center was already mostly killed with the first y90, but this second one seemed to have a smaller margin between the liver and the esophagus so I'm suspecting that there might have been some leakage in radiation between the tumor and stomach.

I'll reach out to her oncologist for more details. Thanks again for responding!

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