I was treated for MAC for 16 months with the Big 3 on an every other day regimen. I was told after a bronch 6 months after I started taking the drugs that the MAC was gone and I had to continue the drugs for 12 more months. Unfortunately I couldn't last more than 16 months total because of side effects of neuropathy and hearing loss. Three months later it came back and the doctor put me on meds every day. I couldn't tolerate the drugs so I had to quit. But my point is when it comes back, I think the doctors move to an everyday treatment protocol rather than every other day. I'm in a watchful waiting period now as my old ID doctor moved to another state and the new one said she didn't think it was necessary at this point. I don't really have many symptoms except for some slight congestion once in a while. I nebulize 7% saline twice a day and use a vest twice a day. A recent CT showed no changes from a CT back when I was supposedly MAC free.