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Foot pain with Anastrozole?

Breast Cancer | Last Active: Oct 28, 2025 | Replies (93)

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Profile picture for deb23 @deb23

I know the original post is old, but maybe more info will help someone.

Yes, I had similar foot pain, especially when standing up after non-movement. I would hobble to the bathroom in the AM, felt like my ankles wouldn't bend and bottoms of feet were sore. But once I walked a few min, it cleared up (mostly). This started after a year or so on Anastrozole for me, before that the pain had been in my hips, knees ... it's like it worked its way down. I've been on Anastrozole for 2 yrs now, and don't have too many aches anymore, but my feet are still tender in the AM. I'm a walker and put in several miles a day, do tai chi, try to stretch whenever I think about it (not enough), but I stay active ... any and all movement helps the situation.

When I brought up the foot/ankle pain to my Onc, he suggested I see an orthopedist. What??? I was just reporting symptoms, as he asked me to. He said no, AI doesn't cause that. I said - but I had NO foot pain before in my life. He said - coincidence.

Of course I do not believe him for a minute. He has never taken it. It is the anastrozole.

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Replies to "I know the original post is old, but maybe more info will help someone. Yes, I..."

@deb23 in my opinion he is 100% wrong. I am super active, always have been, fit with some injuries along the way due to overuse (ie rotator cuff with heavy lifting). The foot pain is absolutely an AI thing. Hard to describe, bery predictable after laying down or legs up/sitting, and goes away but a strange and apparently unexplainable phenomenon. Mine has settled down and gone (again). None of my MDs really had an explanation except "swelling or circulation" which made no sense. They were not tight feeling.

Good luck and hope it completely simmers and doesnt return!!

@deb23

I was on Anastrozole for 5 months before the pain occurred in my fingers, similar to what you have with your feet. If I don't keep moving them they freeze up. It's been 8 weeks since I stopped Anastrozole and still am having pain in the fingers. I was put on Exemestane which started to cause my toes to freeze up like my fingers. I have stopped taking that and am meeting my oncologist this coming week.

For me, right now, I don't want to have each day ruined by pain. I don't know if I want to start anything else when it causes such strong side effects. Life is so short and I want to enjoy each day. I'm 71 and want to enjoy time spent with my husband, dogs and my yard work.