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Capsular contracture following implant surgery

Breast Cancer | Last Active: 4 hours ago | Replies (4)

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Profile picture for Rubyslippers @triciaot

You might want to ask your doctor about this study and if it applies to you. The take-away might be to stop letrozole temporarily. They may also have studies that show which hormone therapy may cause you the least issues while healing. I’m not suggesting to completely stop taking an AI, just temp.

From Science Direct
The link below has more info and DOI link that will take you to the research.

“ Discussion
This study shows that tamoxifen and AIs seem to be associated with an increased risk of wound healing complications (fat necrosis, infection, and delayed wound healing), regardless of the type of breast reconstruction performed, and with an increased risk of Baker's grade III or IV capsular contracture in the case of prosthetic reconstruction. Hormone therapy did not seem to significantly increase the risk of microvascular thrombosis or VTE for breast reconstruction.

Conclusion
In our study, hormone therapy, including tamoxifen and AIs, appeared to be associated with a higher risk of postoperative wound healing complications and capsular contracture.
Our study suggests that temporary discontinuation of tamoxifen or AIs could help limit wound healing complications that may sometimes lead to the failure of the reconstruction, especially in the case of prosthetic reconstruction. A prospective cohort study should, however, be conducted to confirm our findings. . . .”
https://www.sciencedirect.com/science/article/abs/pii/S1748681517302243#:~:text=This%20study%20shows%20that%20tamoxifen,or%20VTE%20for%20breast%20reconstruction

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Replies to "You might want to ask your doctor about this study and if it applies to you...."

@triciaot this is so interesting. May I ask how you came upon it? I will share it with both my plastic surgeon and my oncologist. I am taking singular and vit E twice a day (2,000 ) to help with healing. How long a time does one stop the AI to help promote healing?