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Interesting and encouraging update on Checkmate 274 (adjuvant nivo) with a retrospective on signatera.
https://www.annalsofoncology.org/article/S0923-7534(25)04930-0/fulltext
This week was interesting. My leg aches are less severe but still make it difficult to move around. Especially getting up and down when seated or climbing stairs. My hands and arms now have countless little white spots. The itch is still there but very slight. My hematologist recommends iron IV 3 but I am hesitant as I have concurrent IRAEs and had a deposit in May. He told me that is normal. But based on medical research it may be detrimental to ICI.

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Replies to "Interesting and encouraging update on Checkmate 274 (adjuvant nivo) with a retrospective on signatera. https://www.annalsofoncology.org/article/S0923-7534(25)04930-0/fulltext This..."

@jaxfl Thanks for sharing! My favorite medical oncologist is involved in this study :-). Very sorry to hear about your leg aches. Sides effects are too much sometimes! I started to have mild ones along with some numbness in fingers and toes but had attributed the new aches to a flu shot reaction. On a more positive note, my Pet scan was good and Dr has given me a temporary rest from treatment due to fatigue complete loss of appetite, continued weight loss and new neuropathy. We’ll discuss the new plan in 2 weeks (reduced dosage of padcev and keytruda or keytruda only)
Hang in there!