New diagnosis

Posted by mks1111 @mks1111, Sep 21, 2025

Hey all—58 yo and had first PSA done recently. 9.6. Tumour found and had RARP 3 wks ago. Pathology showed T3aN0 with focal EPE (Gleason 8) and I’m BRCA2 pos.
Any one in a similar situation? Did you get adj rads? Or sit tight waiting for PSA to go up?
Would love to hear experience of others

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mks1111 | @mks1111 | Oct 7, 2025

Hey all—update—first PSA 4 weeks post op was 0.02. A bit early according to my surgeon but ordered by med onc. My BRCA 2 deficiency was noted on the initial biopsy but not on final path. Having more slides looked at as only one block was reviewed in each case. anyone else had this discrepancy? Interested in outcomes

jeff Marchi | @jeffmarc | Oct 7, 2025

In reply to @mks1111 "Hey all—update—first PSA 4 weeks post op was 0.02. A bit early according to my surgeon..." + (show)

@mks1111
It sounds like you’ve had somatic, genetic test, not hereditary, genetic tests.

When the test is on your tissue, from A biopsy, that can show Things like BRCA But they are not hereditary genetic issues. Your tissue can morph into these different genetic problems and then they can disappear.

Have you had a hereditary, genetic test? That probably would not show anything since if you really were BRCA From heredity every test you took from tissue would still show it.

mks1111 | @mks1111 | Oct 21, 2025

Ok all, follow up—radical prostatectomy 7 weeks ago. PSA just came back at 0.008. Does that mean there is some residual disease still present? I know I need to be patient and follow the PSA but has anyone had any experience with ultrasensitive testing? Is this anything I need to worry about?

jeff Marchi | @jeffmarc | Oct 21, 2025

In reply to @mks1111 "Ok all, follow up—radical prostatectomy 7 weeks ago. PSA just came back at 0.008. Does that..." + (show)

@mks1111
Stop worrying. If your result was < .1 You would be considered undetectable. You are way below that. At this point, there is nothing to worry about. See what your follow up PSA test show in three months or so.

Almost anybody that finished a prostatectomy would be really pleased with your result.

dhasper | @dhasper | Oct 21, 2025

In reply to @mks1111 "Ok all, follow up—radical prostatectomy 7 weeks ago. PSA just came back at 0.008. Does that..." + (show)

@mks1111 You are doing fantastic, and your post probably reflects why Mayo doesn't do ultra-sensitive anymore.

mks1111 | @mks1111 | Oct 21, 2025

Thanks guys. Fingers crossed. Hopefully no rise (ever) moving forward

Roxy2017 | @roxy2017 | Oct 22, 2025

Indeed. I asked my RO about ultrasensitive and he too is not a believer. Says it causes too much unneeded anxiety.

surftohealth88 | @surftohealth88 | Oct 22, 2025

In reply to @mks1111 "Ok all, follow up—radical prostatectomy 7 weeks ago. PSA just came back at 0.008. Does that..." + (show)

@mks1111

That is great result !
Different labs have different cut-off numbers that they can measure and consider ultrasensitive.
Our hospital where my husband had RP does not go below 0.015 and WalkInLab has 0.014 etc.

My husband was gleason 9, so ultrasensitive is important , especially since our MO suggested that 0.05 should be trigger for having serious observation of the doubling time and if it is fast than salvage can start at 0.1 , or 0.15 latest.

For us it makes total sense and expecting results of PSA is never fun, no matter if it is ultra sensitive or not .

Wishing you forever undetectable PSA ! 😃🍀