@yorkie67, Welcome to Mayo Connect. We have a village of helpful people here with a variety of lung cancer types represented. I'm so very thankful for the willingness of Mathew K to add to our EGRF discussions! Lung cancer has evolved to include many types of cancer, and the treatments are rapidly changing. I can relate to wanting to know 'what's next', just knowing that there is something else is reassuring. I was diagnosed with ALK positive lung cancer over five years ago. I'm fortunate to be holding steady on my first-line targeted therapy. Over the years there have been advances, and my plan for a second line has even changed twice because of new research, drugs and combinations of drugs. We're always looking toward the next thing. That hope is all we have somedays, but keep doing what you love, and spending time with those that love you. The future of lung cancer has never been more hopeful.

@yorkie67 this presentation from Dr Janne at Dana Farber is about a year old, but he discusses resistance after Tagrisso. (He's one of the co-discoverers of the EGFR mutations in NSCLC.)