Connect
← Return to PMR and depression
Discussion
Polymyalgia Rheumatica (PMR) | Last Active: Oct 19, 2025 | Replies (8)
Comment receiving replies
The short answer is yes, if you have depression and develop PMR it is likely to get worse. The morbidity associated with PMR can lead to depression
This is from AI:
How PMR contributes to depression
Physical symptoms: The chronic pain, stiffness, and fatigue associated with PMR significantly lower a person's quality of life, which can lead to depression.
Comorbidity: Studies show a higher prevalence of depression in individuals with PMR compared to the general population.
Treatment side effects: High doses of systemic corticosteroids, a common treatment for PMR, can sometimes induce depression or other psychiatric side effects
Replies to "The short answer is yes, if you have depression and develop PMR it is likely to..."
Connect
If PMR doesn't make us depressed ... the treatment with prednisone surely will cause mental status changes. Prednisone replaces the hormone cortisol.
https://link.springer.com/article/10.1007/s43440-025-00782-x
-----------------------------
Prednisone dysregulates our cortisol levels and is known to cause a wide range of psychiatric side effects ranging from euphoria to depression.
https://www.mayoclinicproceedings.org/article/S0025-6196(11)61160-9/fulltext