@westernflyer

Thanks for the additional details.

Found the original research paper and ran it through perplexity.ai to find its connection to sulforaphane.

This research paper indicates that sPOM121 boosts the expression of β-catenin, leading to PCa tumor progression and immune evasion.

Inhibiting the sPOM121/β-catenin axis, in preclinical prostate cancer models, halted tumor aggressiveness and strengthened antitumor immunity.

Apparently, Sulforaphane also acts as a Wnt/β-catenin pathway inhibitor, thus the connection you suggest.

However, this particular research paper did not directly investigate sulforaphane, much less suggest a dosage.

Upon further investigation, I found an unrelated Human Clinical Trial investigating the impact of sulfuraphane in BCR. A short AI summary is outlined below:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4390425/
Phase II Trial in Biochemical Recurrence (NCT01228084)
• Formulation: Sulforaphane-rich broccoli sprout extract capsules (each 50 µmol sulforaphane).
• Dose: 200 µmol daily, taken orally as four 50 µmol capsules before breakfast.
• Duration: 20 weeks.
• Outcome: Well tolerated (no grade 3/4 toxicity); about 35% showed modest PSA declines or slowing of PSA doubling time.

A 200 µmol sulforaphane daily dosage (used in this study), is about 3.5-4 ounces of raw, freshly sprouted broccoli (one loosely packed cup) per day.

I like the taste of broccoli sprouts and I started eating one cup per day about 3 months after I was diagnosed in October 2023.

My PSA level dropped from 7.8 (May 2023 - prebiopsy) to 5.8 by February 2024.

Of course, I implemented many diet and exercise changes in the first 3 months after diagnosis, so there is likely to be multiple explanations.

My latest PSA level was 5.76, unchanged over 16 months.

As there appears to be some solid science behind sulfuraphane and now a potential mechanism, I’ll have to add some credit to my broccoli sprouts and HIT to explain my slowing PSA velocity…

Thanks again for this reference!

All the best!