I too have Gastro difficulties on Exemestane, taking it after my dinner meal has helped some. By 18 to 20 month, I had so many side effects on anastrozole I had to go off. These intermittent Gastro symptoms are so minor to the symptoms of fatigue, pain, dry eye, lichen, sclerosis, tendon problems, etc. on anastrozole. I think with all these medicines, you have to find one that is the lesser evil of the others for you and your body.