I’m glad you are here. I have been on the Big 3 since August 10. Azithromycin, Rifampin and Ethanbutal every day. Hearing from another member, I space them out, Azithromycin in the morning after breakfast. Rifampin mid-afternoon on an empty stomach and Ethambutol at night. I haven’t had any side effects and there are lots of people who sail through without a problem. I hope you will be the same. I am treating this like a job, I don’t miss a dose, and hopefully my MAC will clear and I can continue doing airway clearance and exercising and eating carefully and stay off the antibiotics. Good luck and know that you are doing all that you can to progress to good health!