Two years ago my kidneys went from normal to stage 3a CKD in a day or so. I am 71 and was very athletic, got covid on a March bike tour, then months of long covid (LC spikes in systolic pressure), kidneys fine. Then in December I caught norovirus with dehydration from projectile vomiting and diarrhea, high temperature, and LC blood pressure spikes. My eGFR went from 73 before to 56 after, but decreased to as low as 39 the next summer. Nephrologists generally put patients on ACE inhibitors to lower blood pressure (protects kidneys), even though my avg. resting HR was 120/70 (now 103/73); I can't tolerate them so am now on Jardiance, an SGT2 inhibitor that is for type 2 diabetes, high blood pressure, and heart disease (none of which I have). It seems to have stabilized my eGFR to 42. One generally isn't prescribed SGT2 meds with an eGFR below 45, but there are exceptions. There is also some current research on Ozempic for people with Type 2 diabetes or CKD: https://www.kidney.org/news-stories/fda-approves-ozempic-type-2-diabetes-and-chronic-kidney-disease https://pmc.ncbi.nlm.nih.gov/articles/PMC9263228/ https://www.nature.com/articles/s41598-024-81973-z