@beachy - The best next steps are all super hard to figure out when you are experiencing what seem like extreme side effects. I am not medical staff in any sense, but this is what happened in my experience: I eventually got so weary of the extreme cramping, random vomiting and bad diarrhea that even caused a little "explosion" in my bed twice overnight, that I finally asked my doctor to switch me from semaglutide (Wegovy) to tirzepatide (Zepbound). She agreed that my side effects were bad and put me on the path to a switch.

In the end, I feel like this was a mistake for me, simply due to time constraints with my insurance coverage. I had to be off all weight loss meds for one month, to be sure the side effects were coming from the semaglutide (Wegovy). They were, and all side effects stopped. Then I had to wait a little for my insurance to authorize the tirzepatide (Zepbound). During this time off of the shots, my weight went up quite a bit. Then I had to start all over with the tirzepatide (Zepbound). By the time I got to the top dose, my insurance coverage for weight loss shots had run out. And for whatever reason, the tirzepatide (Zepbound) did not work for me at all - I lost maybe 1 pound total on it. I'd lost 53 pounds in my time on semaglutide (Wegovy). I essentially went backwards in my weight loss, which was frustrating.

So, in retrospect, I wish I had stayed on the semaglutide (Wegovy) and figured out with my doctor how to work with it and the side effects (e.g., going down in dosage, frequency of shots, antidiarrheal meds).

Ultimately, only you can say what is the best path for you, beachy.

Hoping perhaps other members in this discussion on weight loss shots such as @edwardw @therese0327 @writer418 @projfan @ekrahenbuhl will have some input for you on the nausea/vomiting/cramping side effects you've had to deal with as you try to determine how to manage this and the way forward.