@kelley5454 Pulmonary told me that any skin or dental side effects, if they were to show up, appear months into treatment. Keep brushing and flossing and thinking positive thoughts!

@kelley5454
I was able to access the NEJM info on the phase 2 study and Ann clipping the info about dental that might help you. I can't access the more recent on Phase 3 without paying.

From Chalmers, NEJM, 2022.
""All the patients, excluding those who were edentulous, underwent dental assessment at baseline and at weeks 8 and 24."

Further in article, this:
"Across the trial groups, the numbers of patients with dental sites that had an increase of at least 2 mm in the pocket depth and an absolute depth of at least 5 mm (the threshold of concern in periodontal disease18) were evenly distributed, which suggests that there was no difference among the groups in the progression of periodontal disease. "

I am not eligible and haven't followed it closely, but as I read thru looking for you'd info, it sounds like like an exciting development. This is a about from Chest Physician “The most shocking thing from the study was the impact it had on FEV1,” said Charles L. Daley, MD, FCCP, Chief of Mycobacterial and Respiratory Infections at National Jewish Health and ASPEN site investigator. “The decline in FEV1 slowed significantly. You can tell someone that if you go on this drug, there is a good chance your pulmonary function is going to remain better than if you don’t."

. Having them check at 8 weeks and 4 months might be a place to start. It would be better if you could get access to NEJM's article on last phase for the data on the larger group.
Good luck!

I heard a researcher explain the it is people with a genetic defect called Papillon–Lefèvre syndrome (PLS), that have problems with skin & gums already who are those affected by brinsupri. As long as you print out the information about brinsupri for your dentist & have regular dental and dermatology check ups, you should be fine.