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What’s up with these toe infections?
Neuropathy | Last Active: Oct 17, 2025 | Replies (12)Comment receiving replies
@db72
I believe the cause of infections in feet/toes from neuropathy (small fiber) may be due to poor circulation in blood vessels, damaged nerve signals for sensations and function which increases risks for infections. That is why many with diabetes also have small fiber neuropathy damage and foot/toes infections. Some need toes/foot amputation as a result of neglected infections.
Do you have small and large fiber neuropathy damage? Did you have the small fiber neuropathy skin punch biopsy to diagnose plus EMG/nerve conduction studies of upper and lower limbs for neuromuscular health? Have you seen a vascular specialist to check for peripheral artery disease in legs/calves/feet?
Have you had extensive neuropathy bloodwork and does it show any high glucose/A1C and/or abnormal vitamin B6/B12 levels (deficiencies or toxicities)?
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@dlydailyhope thanks for the input. I have large fiber Idiopathic Axonal sensors-motor Polyneuropathy. Neurologist said it’s not small fiber. Yes, every test was done, EMG and nerve conduction studies, autoimmune, CT scans - the whole nine yards. No PAD or diabetes.
I’ve had ME/CFS for 40 years that was triggered by a severe Epstein Barr infection that damaged my nervous system. My neurologist believes my neuropathy is a result of an autoimmune process caused by the EBV virus.
Your explanation of how nerve damage can cause these infections makes perfect sense.