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PSA relative to prostate size - anyone been told this?
Prostate Cancer | Last Active: Oct 24 6:52pm | Replies (13)Comment receiving replies
Yes. The ratio of PSA to prostate volume is referred to as the PSA Density. PSAD helps interpret PSA levels in the context of prostate size. The PSA Density is another marker that you should be tracking while on AS.
Other markers to track while on AS are: % Free PSA, PSA Doubling Time, and PSA Velocity.
Other information helpful to know:
> What PIRADS score resulted from your MRI?
> What SUVmax scores resulted from your PSMA PET scan?
> Have you gotten a second opinion on your MRI, biopsy, and PSMA PET scan images/tissues?
>?Have you had a biomarker (genomic) test?
> Have you had a genetic (germline) test?
With a 6(3+3), let the other test numbers guide your next steps. With all those numbers and scan/test results, you’ll have a better grasp on what’s really going on
(Him saying "Something is going on with your prostate” isn’t quantifiable or testable.)
Replies to "Yes. The ratio of PSA to prostate volume is referred to as the PSA Density. PSAD..."
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@brianjarvis
Other information helpful to know:
> What PIRADS score resulted from your MRI?
I've had 2, 1st in August '24 and another in August '25. In '24 PIRADS score of 3 with one suspicious lesion in peripheral zone. In '25 no PIRADS score given, but this notation, "No MRI evidence of clinically significant prostate cancer. Previously noted PI-RADS 3 lesion in the left mid gland is no longer discretely seen."
> What SUVmax scores resulted from your PSMA PET scan?
I can find no reference to SUVmax score in my PET result. The only information that I can decipher is this, "Prostatomegaly with no focal increased uptake on a PET/CT scan." and the note "No evidence of extraprostatic disease." I looked up the former and it seems like favorable news, and the latter seems self-explanatory.
> Have you gotten a second opinion on your MRI, biopsy, and PSMA PET scan images/tissues?
Yes, New York pathology found 5 of 12 cores at 3+3 and 2 of 12 at 3+4. NC Path found nothing but 3+3, and recommended AS with 6 month PSA test and repeat biopsy after 2 years.
>?Have you had a biomarker (genomic) test?
I requested the Decipher test (based on my reading here) of my NY doc, and he ordered the GPS instead as he is familiar with it. Scored 24, likelihood of disease progression=lower. His comment was, "under 20 is great, over 40 is very bad, but in between is not particularly helpful."
> Have you had a genetic (germline) test?
Not sure if this is what you are after, but I have a family history of cancer (breast, pancreatic and bladder), with BRCA2 present in 2 of my sibs, but I have tested negative for BRCA2.
Thank you for your input!