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Brinsupri follow-up

MAC & Bronchiectasis | Last Active: 1 hour ago | Replies (128)

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Has anyone experienced respiratory infections, additional wheezing, and/or nausea and shakiness upon taking Brinsupri? I started the 10mg dose on October 2nd, and I find that I get super nauseous after taking it, even when I take it with food. I also currently have one of the worst lung infections that I have had in a long time, pretty much aligning from when I started Brinsupri (it does not mean it is related but it makes me suspicious). I was put on moxifloxacin for a week (I took my last one today), and my sputum production is just as bad as before, and my wheezing is much worse.

I have also been getting incessant nosebleeds (I have never had a nosebleed before) but that may also be related to a nasal polyp I have that has gone unaddressed but thought it was worth mentioning. My doctor does not think my infection is related to Brinsupri either but I just do not know. I have been called in Ceftin and am going to start that antibiotic if my symptoms are just as bad tomorrow. I have been following my bronchiectasis regimen as well, which is using my percussion vest up to 3x a day while nebulizing (either albuterol/ipratropium or 7% NaCl solution), I typically use the NaCl solution because I feel like it works better for me for clearance. I also practice the “huff cough” breathing technique daily.

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Replies to "Has anyone experienced respiratory infections, additional wheezing, and/or nausea and shakiness upon taking Brinsupri? I started..."

@sdugan001
Welcome to Connect, a very helpful group. It sounds like you're having a pretty tough time. Have you sent in sputum culture? That might give useful info to guide antibiotics. Does your doc know about the nose bleeds? I'd be sure to tell him.

@scoop will likely comment and is taking it.

@sdugan001 What a bummer you are experiencing these symptoms. Although Brinsupri has not caused any issues in me so far, stomach issues and/or headache can occur when you first start it according to my doctor. That said, moxifloxacin alone can cause stomach discomfort, as can any antibiotic. I agree with @pacathy that a sputum culture is critical. Personally, I would not start another antibiotic until I dropped off a sputum sample for culture. I hope you feel better soon!

FYI – so far my experience with Brinsupri has been positive. I’m entering my 4th week and my previous random hacking cough jags are now rare, with mucus lighter in color and less of it, and clearance time seems quicker than before starting Brinsupri. I've just now come from a dental appointment (a restoration, which was at least 2 hours in a supine position) and did not cough once!