@greatgrandma2025
I can't really explain it to you except I know it's one of the tests that is done for molecular/genetic testing.
I copied this from Google search:
"POLE (polymerase epsilon) testing is a genetic analysis used to identify mutations in the POLE gene, which is involved in DNA repair. Mutations in POLE can increase the risk of developing endometrial cancer, a type of uterine cancer.
Purpose of POLE Testing
POLE testing is used to:
Identify high-risk individuals: Women with POLE mutations have a higher risk of developing endometrial cancer and a poorer prognosis.
Guide treatment decisions: POLE-mutated endometrial cancers are typically more responsive to certain treatments, such as chemotherapy and immunotherapy. "

@greatgrandma2025
POLE is a gene that is mutated in about 10 % of endometrial cancers. This is a mutation that is only in the cancer, not one that you inherit from your parents and that predisposes you to getting cancer (very, very, very few people have an inherited POLE mutation.). In other countries, endometrial cancers are routinely tested for mutations in POLE, but not in the US. Getting your tumor tested for POLE usually requires pulling some teeth. You hope your tumor has a POLE mutation because it confers a much better prognosis, even without treatment.