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What are Short-term ADT's long-term side effects?
Prostate Cancer | Last Active: 14 hours ago | Replies (14)Comment receiving replies
I had ADT for 6 months prior to my surgery as part of a trial which also included Olaparib (Lynparza). The NepTune trial is for BRCA mutation patients - I'm BRCA2 +. The olaparib wasn't fun at the beginning - caused lots of digestion issues but after 2 months got better. The 6 month Lupron Depot shot was a bear - first on how sore I was initially from the shot and the side effects. Completely lost interest in sex, no erections, testicles got smaller, lost some body hair, lost muscle mass, fatigue, and many small injuries from exertion - specifically back and shoulder. My bloodwork 2 weeks after surgery still had my testosterone at zero. Next month I have my 3 month post-surgery visit and hoping that my T levels are climbing. My onco said that my T levels should come back within 6 months.
Replies to "I had ADT for 6 months prior to my surgery as part of a trial which..."
@jmacpa
I’m really surprised about you being sore after the Lupron shot. I got them every six months for six years and unless I pressed right into the spot where they gave the shot, I never even felt it. They gave it to me in the hip. Where did they give it to you?
How were your blood counts after being on olaparib? It’s known to really suppress the platelets white blood cell counts and more. I got paid to review some documentation on its side effects and they were pretty scary. I was actually on it for about a week and had nightmares every night like I’ve never had before. My oncologist let me switch to Nubeqa And I’ve been undetectable for almost 2 years. Had PC for 15 years and found out about my BRCA2 five years ago. My oncologist wants me to wait until Nubeqa Fails because the PARP inhibitor is so hard on the body. Some of my blood test results show me close to anemia, and it would almost definitely push me into it.
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@jmacpa
Thanks for sharing. I'm sorry to hear you hear about your adverse side effects. As brianjarvis said, each man is different. I guess it's a game of odds.
Good luck with your recovery.