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Where are all the people on Active Surveillance (AS)?
Prostate Cancer | Last Active: Oct 26, 2025 | Replies (59)Comment receiving replies
@handera appreciate that. my most recent MRI was downgraded from a Pirads 3 to a Pirads 2 but I’ll continue with regular PSA tests and monitor prostate density, velocity etc. My urologist still believes I would benefit from a biopsy but I asked him what would be targeted he said “there is nothing to target” I guess implying maybe the MRI reading missed an undiagnosed cancer. But my prostate volume did decrease from 95 to 70ml which could also be connected to BPH. But I’m still hoping that diet and regular vigorous exercise will have some impact.
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@ezupcic One of the “cutting edges” of PCa research is related to the importance and ultimately the aggressiveness of lesions that are “invisible” (or low grade) in a mpMRI.
The question to be studied is: If a mpMRI doesn’t find any visible or concerning lesions, should you continue to recommend a follow up biopsy?
It turns out that prostate cancer is the ONLY cancer where some practitioners will continue to recommend a biopsy, when nothing of concern is found in a mpMRI.
Here’s Dr. Mark Emberton’s take, which I found quite helpful.