@brianjarvis Although the results are as you describe them, the biochemical process is more complicated than that. Eligard, Lupron, etc. are T agonists that stimulate the pituitary gland to temporarily produce more T (the flare). The outcome is that the pituitary down-regulates the T receptors and T levels drop. Orgovyx and Degarelix are examples of T antagonists that bind to the receptors and block the pituitary from producing T. This results in an immediate drop in T. I’ve probably oversimplified, and I’m not a biochemist or physician, so please correct any errors in my explanation.