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Did you know that immune disorders are the cause of bronchiectasis in about 10% of patients! Immune disorders are rare, much more so than bronchiectasis, and difficult to diagnose.
A few years ago during a routine visit to the allergist I was told I had mildly low IgG2 subclasses, along with a poor response to the pneumococcal vaccine. A year earlier pulmonologist said my blood work and response to pneumonia vaccine were fine. Immunoglobulin replacement therapy ensued with some modest relief but not what @kpger describes. With the advent of Brinsupri (along with daily Allegra), I expect that my treatment will be revisited at next immunologist meeting. I've had recurrent sinus infections mostly but they migrated to my chest, exacerbating the bronchiectasis. It's been amazing to me how much daily Allegra has helped my sinuses, and consequently my lungs.
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@scoop I too am trying Allegra for my sinus drainage that so negatively impact my lungs. Could you share the dose and frequency of your use and also any side effects?
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@scoop I didn't know that about bronchiectasis and immune disorders. Maybe that's why they don't routinely check for it. I'd had IgG, IgA and IgM (totals) done on occasion and they were always within normal limits. This doesn't always give the whole picture. What my actual diagnosis is Specific antibody deficiency with normal immunoglobulin concentration and normal number of B cell (HCC); IgG2 subclass deficiency (HCC). I can't tell you what it all means, but I know after starting the infusions I've had fewer hospitalizations and serious illnesses. I've asked the immunologist if I'll ever be able to stop the IVIG and she said no. I'm also at the maximum dosage. Good thing I have a really good infusion nurse......we spend a lot of time toether.
I take Zyrtec daily as well and just started with Chlor-Trimeton. One tab nightly at bedtime. This has greatly relieved the post nasal drip and cough.