@mtstack I too expected the IV to go into my arm, but they told me that b/c of how powerful these cancer fighting drugs are, they have to use small veins and it has to go slowly. My chemo sessions were between 3 and 5 hours each time. As I also reacted to the one drug, they had to do the Benadryl by IV as well, and saline clean between each drug. It wasn't painful in any way...just a long session. We also had a 2 hour drive just to get to the hospital, so it was a lot of sitting. The patients also had a choice of lying down in beds, so I felt well looked after. I was also given a powerful anti nausea drug each time that worked until the 3rd day. Ask for anti nausea pills and take them!