I too have had multiple tests which show nothing. Have been put on Xifaxin for two weeks and I felt worse. Was told I have a fructose intolerance and to eliminate fructose-this did not resolve my problem either. I get every 1,2, or 3 days a feeling like I have appendicitis pains which last about 5 hours. This pain feels like hell on earth for me. Nothing relieves it. Have been to multiple doctors including at the Cleveland Clinic. Lost weight (50 lbs) by intermittent fasting 2.5 years ago. 1 year later, I felt good and then BOOM thought I might be hospitalized for what seemed like a severe UTI and flu combined. (Was tested and found to be covid (-) Was put on a sulfa drug and two days after finishing the sulfa drug, experienced the appendix area pains which went into my back on the opposite side and up to the waist on the right side. The pain is so bad that I have prayed to God to "take me home" at times. I asked my doc why I have lost weight and have gotten worse with blood pressure that is not lowering and increased tinnitis. He said I am just maybe just aging. Found something unusual though. When I go to visit friends in Florida, I take hormone testing at Life Extension/Fort Lauderdale. In Dec 2024, my IGF-1 was 195 (cut off for normal is 196). In March 2025, my IGF was much higher (beyond range), In Sept 2025, my IGF-1 was 90 points above range. When I contacted my primary doc's office (just walked in) my doc came out into the waiting room and said he was going to order a MRI to check the pituitary gland. Google: pituitary adenoma. This can also affect the GI system quite severely