@bprather

Have you had more autoimmune testing beyond the MI-2 testing/result? Are you working with a rheumatologist?

Here is what MI-2 is described as in AI:

A positive Mi-2 result, typically referring to the presence of Mi-2 autoantibodies, is often associated with autoimmune conditions, particularly dermatomyositis and sometimes polymyositis.
Understanding Mi-2 Autoantibodies

Significance of Mi-2

Dermatomyositis: The presence of Mi-2 antibodies is considered a marker for this condition, which involves skin changes alongside muscle inflammation. Patients often present with characteristic rashes and muscle weakness.
Clinical Implications: Mi-2 antibodies are usually associated with a more favorable prognosis compared to other autoantibodies like Jo-1.
Symptoms of Dermatomyositis

Skin Rash: Typical rashes include heliotrope rash (purple rash on the eyelids) and Gottron's papules (red or purple bumps on the knuckles).
Muscle Weakness: Proximal muscle weakness is common, affecting shoulders, hips, and neck.
Diagnosis and Management

Diagnosis usually involves a combination of clinical evaluation, laboratory tests for autoantibodies, EMG studies, and sometimes muscle biopsy. Treatment typically involves immunosuppressive medications such as corticosteroids or other immunomodulators.