← Return to Zometa (Zoledronic acid), should I take if not on AIs?

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Profile picture for aubreybill @aubreybill

Wow not much discussion on the topic of prevention - little surprised. I am a 73 year old female (active, daily exercise/healthy diet & weight) with breast cancer return after 25+ years (years ago had bilateral mastectomy - cancer did not involve lymph nodes/followed with 7 years of tamoxifen). April 2024 noticed a lump under my arm and was cancerous - Stage 3/4 estrogen receptive - somehow a breast cancer cells were left behind and moved into my lymph nodes. Oncologist want me to do CHEMO but I declined due to my age so they put me hormone inhibitor Anastrozole and regular MRI's showed significant cancer size reduction. February 2025 had surgery - they removed 25 nodes with 11 still showing cancer, also the next month had 16 rounds of radiation for mop up. Oncologists wanted me on Verienzo - tried for month but had to stop due to lower GI side effects. So still taking Anastrozole with achy body, fatigue, sleep issues - oncologist recommended infusion of Zometa to prevent my breast cancer moving into my bones - first infusion August and will have every 6 months for next 3 years. They are pretty much done with me unless I notice a lump or some problem indicating a cancer spread/return. I would like to do something more preventative like ANKTIVA (BioShield) to improve my T-CELLS to fight off the cancer cells but the only thing my doctors could recommend was the Zometa infusion that only addresses bone metastasis. I am frustrated that I have to wait for a cancer return and cannot be more proactive w/o major destruction of my own healthy cells. Would appreciate any input and if other cancer patients able secure preventative treatments like ANKTIVA to enhance our own bodies to fight off our cancer.

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Replies to "Wow not much discussion on the topic of prevention - little surprised. I am a 73..."

Hi! @aubreybill:

I am so sorry for what you've been through:( It must have been a terrible shock upon learning of the recurrence of BC after 24 years! My heart with prayers goes out to you upon reading your post...

Thanks for sharing your insight with us. Your spirit of resilience and diligent searching for the prevention of recurrence really inspire me! Thanks for sharing your experience! As far as I understand, ANKTIVA medication is used for the treatment of bladder cancer. It is an interleukin-15 receptor agonist and was approved for medical use in the United States in April 2024, so it is kind of new. Perhaps this is the reason that your medical oncologist hesitates to prescribe it to you, for it is primarily used to treat bladder cancer. I am wondering whether you've taken genetic testing for cancer already; for if you haven't done that, it might be useful to ask for it. If there's any inherited abnormal mutations in your DNA, physicians may be more willing to try Anktiva on you for prevention of cancer. Unfortunately, I am not any expert but only a patient with BC:( Personally I took the genetic testing for cancer primarily for my blood relatives' sake, just wanting the forewarning to prevent it from happening - should there's any abnormal mutations in my blood.

Wishing you all a great journey ahead with better health, hope, peace in mind and love to enjoy your family and friends!