@mandie4712 It bothers me so much when I hear that people are terrified by a med like Tymlos. My experience has been so benign overall. When I started taking it in January 2024, I experienced occasional mild nausea that started soon after the shot and that lasted up to two hours and also very occasional rapid heartbeat for a few seconds (I have a mild arrhythmia called superventricular tachycardia, which means my heart sometimes has run of six or seven rapid beats. It's only occasional and for all I know these weren't caused by the Tymlos, but it is a listed side effect, so take it for what it's worth). Anyway, I changed the time of day I take the shot (from early evening to bedtime), and both side effects promptly vanished.

What happened with me may have exactly no relevance to what will be your experience. But I have absolutely no side effects from Tymlos now, and have had none for most of the time I"ve been on it. I know other people have had a very different experience. But you can regulate the dose and start slow and work up, which has helped mitigate the side effects for some people.

In any case, all of the Tymlos you inject (or most of it, I'm not really sure which) is out of your system in something like an hour and half, which is one reason the side effects are so time limited. It's not like Reclast where you get a shot once a year and the med stays active in your system.

Talk to your doctor. But for me Tymlos has been wonderful. I don't love doing the shot, but it takes literally two minutes. In exchange for that, my spine improved from -3.3 to -2.6 last February, and I'm hoping it will be even better when I have my next DEXA scan, in February.

Tymlos seems to work best on the spine, so if your problem is, say, your hip, it might not be as effective for you. That's a question for your doctor.

Good luck. I was pretty stressed about starting Tymlos, but after a compression fracture I had no choice. I hope things work out well for you.