I have been on prednisone probably longer than any other human alive. I started when I was a teenager with JRA back in 1971 as I was allergic to aspirin and there were not many treatments. I was off it a number of years but have been on it for over 30 years now. I have had bad side effects from many biologics over the years so prednisone has been the only stable option for me. I had lung cancer 13 years ago and had to stop all other meds. I have weaned down to a very small dose and my RA is well controlled with xeljanz and methotrexate. But a bone density scan with added vertebral fracture assessment back 10 years ago showed loss of bone density and 3 spinal fractures. I am on prolia now with good success. But damage remains - I had one hip replaced last fall (necrosis and bone on bone) and am trying to get the other done ASAP. I have developed anemia and am having a bone marrow biopsy next week.