Hi @survivor5280 -- I agree with your sentiment that trying to "explain away" a high psa, or using various supplements/diet to try to treat PCa is not a good idea. However, the article surftohealth88 identified above is a very different issue; that the presence of biotin in the blood serum may interfere with an accurate psa test result depending on the level of serum biotin and whether the assay method is using the biotin-streptavidin design. This is simple chemistry for the assay types that depend on this chemistry for measuring psa. I then checked the assay method used for 3 of my last 4 psa tests and it was one that uses the biotin-streptavidin design, so it can report an artificially low psa if biotin supplementation is being taken. I then checked Quest Lab's clinical guidelines, and they suggest abstaining for 72 hours from taking very large doses of biotin before doing blood tests. Although the quantities they cite are much higher than the amount found in my B vitamin supplement (which gave me some degree of comfort), since I'm interested in detecting even minute changes in my psa I'll definitely skip my B vitamin supplement for a couple days before my next psa test. I want that psa number to be as accurate as possible. Best wishes.