@surftohealth88
Yes, getting on estrogen instead of ADT does sound attractive, But there are a few issues.

If you have BRCA, you can’t do it, Estrogen is going to cause nothing but problems and accelerate prostate cancer issues.. If you do take estrogen, you need to get your chest x-rayed ahead of time, or very early to prevent gynecomastia. At the ancan.org Meeting Tuesday one of the guys said he even had a mastectomy because his breast were getting too big. Estrogen sounds like a great deal, but it has its drawbacks.

Adjunct radiation was discussed at the Ancan.Org meeting on Tuesday, when @soli showed up and discussed his desire to do adjunct radiation. @soli is pT3b and has a decipher score of .75 (already discussed in another message on this forum), so he does fit the criteria Dr. Efstathiou recommended.

Dr. Efstathiou concluded as follows:
* Early salvage radiotherapy is favored over adjuvant radiotherapy in most patients
* Consider adjuvant radiotherapy in otherwise fit, motivated, very high-risk patients with ≥2 of the following risk factors:
* pT3b-4
* Gleason score 8-10
* pN+ Lymph node Metz
* Decipher score >0.6

We then had a discussion About side effects for those that had prostatectomy following by salvage radiation. A number of side effects were experienced by people in the meeting. Most of them happened years after the initial radiation. Like my experience with incontinence five years after salvage radiation. The radiation does harden the urethra and that’s probably why incontinence occurs. @soli is aware Of all of these possible side effects. It could be getting a really good radiation oncologist can prevent many of them. Some people had rectal bleeding, But the rectum isn’t in the prostate bed, so maybe getting a really good radiation oncologist can eliminate that kind of issue. Other people had bladder issues, But the bladder isn’t in the prostate bed so better radiation techniques should eliminate it.

Yes, adjunct radiation could be chancy, but having it done by a real good doctor and team, could avoid most side effects.