@irenea8 I've been on Brinsupri for about 2.5 weeks, and I am also taking an almost daily Allegra, which I began before Brinsupri. On the Allegra alone I noticed lighter less sputum but still plenty of phlegm for each airway clearance session. It seems a lot of nasal drainage was ending up in my chest. The Allegra alone has helped that little doubt. I have asthma along with an allergic profile in general. Enter Brinsupri, and 2.5 weeks later I can say there is even less mucus now and my chest is not as wheezy or crackly, and I am coughing way less. In the morning I still feel the need to clear but the process seems faster.

I asked my doctor about the side effect of respiratory infections, and they said they just don't know, that less than 20% of patients in the studies participated in daily airway clearance. So respiratory infections cropped up, plus it was studied during covid. It's not known how Brinsupri will help those with MAC or pseudomonas or fungal infections. From my point of view there's little downside to trying it, assuming you can get insurance to pay for some or all of it.