Congratulations! Good luck! My signatera was negative again fortunately 2025-09-26. I do not keep a spread sheet. I use a basic text file to track major IRAEs by start date and duration. I send portal messages to the care team with noticeable side effects. In my case they had me come in once so far for suspected colitis in April. They prescribed a topical steroid twice recently for the rash. Otherwise for other benign side effects they typically make supportive suggestions (OTC and rest and the like).

Consider adding akkermansia, CBM588, camu camu and antihistamines (Zyrtec, Claritin) to boost ICI. Plus request early morning infusions (chronotherapy) and stay active.

Mayo tends to get annoyed with incessant messages about anything and everything so in my case I have to reach out sparingly. Maybe your care team will be more receptive. I understand why Mayo prefers limited communication: they treat many patients obviously.