← Return to Adjuvant radiation and ADT after radical prostectomy: Thoughts?

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Profile picture for Jeff Marchi @jeffmarc

The fact is that jump in PSA is really pretty irrelevant. You need to see the next PSA or two PSA tests to see if you’re really having a rise. You should be getting tests monthly to see what’s going on.

I like the fact that your doctor is being proactive. Adjunct radiation has been shown to make a big difference for some people that have a combination of issues. I’m not sure what your specific issues are, but here is some information from a real Genito Urinary Oncologist Who is one of the top people in the field?

Take a look at the following, which tells you which patients should have early radiation (adjunct), See if Your situation matches what she has described. If this doesn’t match your situation, talk to your doctor about this. You did not supply enough information for us to advise you.

Dr. Efstathiou concluded as follows:
* Early salvage radiotherapy is favored over adjuvant radiotherapy in most patients
* Consider adjuvant radiotherapy in otherwise fit, motivated, very high-risk patients with ≥2 of the following risk factors:
* pT3b-4
* Gleason score 8-10
* pN+ Lymph node Metz
* Decipher score >0.6
* In high-risk patients, use lower thresholds to initiate ‘ultra-early salvage or adjuvant-plus’ radiotherapy
* If giving adjuvant radiotherapy, it implies high-risk disease. Thus, Dr. Efstathiou would recommend treating the prostate bed and pelvic lymph nodes, in addition to short-term versus long-term ADT, depending on risk factors
* May consider genomic classifiers or artificial intelligence tools to help with informed decision-making
* The goal is to avoid (or delay) radiotherapy in those who we can, without missing a window to cure patients who are guaranteed to recur

Here is a link to the article supplied by @surftohealth88 originally
https://www.urotoday.com/conference-highlights/apccc-2024/151546-apccc-2024-debate-how-to-best-manage-a-fit-patient-with-high-risk-localised-and-locally-advanced-prostate-cancer-how-to-select-patients-for-adjuvant-therapy-after-radical-prostatectomy-and-how-to-treat-them.html

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Replies to "The fact is that jump in PSA is really pretty irrelevant. You need to see the..."

@jeffmarc
Thanks very much! This is very helpful. Btw - my TNM stage is pT2cN1Mx

@jeffmarc
Great article. Thank you. I am trying to figure out what this says about my next steps given I have the following risk factors: pT3b disease. Decipher score of .75. My first PSA test after surgery will take place the first week of November.

Should I consider additonal treatment regardless of what my PSA is, or only if it is above a certain threshold? If so, what is the threshold? What treatment does this study recommend in my case? What are the typical side effects of the recommended treatment?

I appreciate any clarifications for my specific case.