This combo is the exactly what I was put on for Stage IV non-small cell lung cancer (adenocarcinoma).

The first week totally sucked! I mainly had really bad fatigue and chemo brain. Kind of felt like I've been hit over the head with a baseball bat! Wasn't nauseous, so that was a surprise.

I think the worst side of that was the one that I didn't know existed on chemo, and that was mouth sores. It got so it was painful to my mouth to even drink water! We called the doctor, and he told me that it was not an uncommon side effect, and that there at Mayo (one of the smaller clinics), they had developed something that they called magic mouthwash. It changed my life. I was on that regime of every 3 weeks for five infusions. The other four infusions we're a little better, mostly because I had a better idea of what to expect. I knew when it was almost time for my infusion because I almost started feeling human again!

They sent me to get a PET scan, and my nodules had reduced by over a half, which I thought was pretty cool. They changed my regime by pulling the Alimta. 90 percent of my symptoms just vanished. I've had two infusions like that, and other than some moderate fatigue ,I'm feeling pretty good. I've read all kinds of terrible stuff about Keytruda as well, but I don't seem to be having any negative side effects from it, that seemed to all come from the Alimta.

I meant to send this as a reply to the original post. Didn't mean to bother you Doug!

So, there's my experience. Your mileage may vary.

Sandy