@ltj My lumbar t score was -3.2 or -3.3 for a few years before I started Tymlos, when I was on Prolia. I didn't lose bone mass but I certainly didn't gain any.

I took raloxifene from 1998 to 2006, when I developed a massive DVT that may have been caused in part by that drug. I switched to Fosamax but had a real problem with GERD. So in 2010 I stopped that. My lumbar t score at that point was -2.5. I am embarrassed to admit that I took nothing for ten years, until I had another DEXA and my lumbar t score was -3.2. It stayed there, bouncing between -3.2 and -3.3, for four years, while I was on Prolia. So it stabilized but didn't improve. I had that lumbar fracture in October 2023 and at that point my endo switched me to Tymlos, and we won't know exactly how well I did until I have another DEXA in February.

I know you read a lot about side effects, but I wonder if many of the people who write about them are the ones who do have real problems and people who do well don't bother to post. The Tymlos pen allows you to adjust the dose, so you can ramp up if necessary, if your doctor approves.

Good luck. This disease is incredibly stressful, not least because the treatments all have potential drawbacks. Hope you do well.

@ltj I don't think I specified, but my lumbar t score after one years on Tymlos was -2.6, barely in the osteoporosis range. Can't wait to see how it comes out in February.