@tjp1958
It definitely looks like the cancer has spread beyond the prostate. I would imagine that if they’re doing MRI guided radiation, they would’ve hit the area that looked like it had spread to. You could ask the RO If that did happen just to confirm that they did cover that area and you Have “clean margins” as far as radiation is concerned.

That would be the only thing I would be concerned with. You are all 3+4 or less And nothing else that is looked for to be possible to escape radiation is in your biopsy.

Overall, it looks real good.

AI Overview
In a prostate cancer biopsy report, "tumor extends into loose fibroconnective tissue at the end of the core" means the cancer has likely spread beyond the prostate gland's boundaries. This is also known as extraprostatic extension (EPE) or extracapsular extension.

Here is a breakdown of the key terms:
Loose fibroconnective tissue: The tissue just outside the prostate. A pathologist views this material at the end of the biopsy sample, which marks the outer edge of the prostate.

Extends into loose fibroconnective tissue: The cancer cells are seen invading this tissue, which suggests they have broken through the prostate capsule and spread beyond the gland.